منابع مشابه
Formulation and Evaluation of Immediate Release Tablet of Carvedilol using Liquisolid Compacts Technique for Solubility Enhancement
Aim: The aim of this study was to formulate and evaluate liquisolid compact system of carvedilol to give increased dissolution rate of drug by utilizing PEG400 as the non-volatile liquid vehicle. Materials and Methods: The liquisolid tablets formulated with PEG400 at different concentrations. The suitable analytical method based on UV-visible spectrophotometer was developed for carvedilol. Resu...
متن کاملDevelopment of a Self Micro-emulsifying Tablet of Cyclosporine- a by the Liquisolid Compact Technique
Purpose: The aim of this study was to enhance the dissolution rate of Cyclosporine A, a poorly water-soluble drug by developing a self micro-emulsifying (SME) tablet formulation by using the liquisolid compact technique. A liquisolid system is formed by converting a liquid formulation into a dry, free-flowing and compressible powder mixture with selected carrier material and coating material. T...
متن کاملLiquisolid Technique for Enhancement of Dissolution Properties of Fenofibrate
The in vitro dissolution property of slightly water soluble Fenofibrate (FN) was improved by exploring the potential of Liquisolid system (LS). The in vitro release pattern of LS compacts and directly compressed tablets were studied using USP-II apparatus. Different LS compacts were prepared using a mathematical model to calculate the required quantities of powder and liquid ingredients to prod...
متن کاملEnhancement of Dissolution Properties of Amlodipine Besylate Using Liquisolid Technique
The most promising method for enhancing solubility, therefore promoting the rate of dissolution is the formation of liquisolid compacts.[2]With Liquisolid technique as described by Spireas liquid formulations such as solutions or suspensions of poorly soluble drugs in a non-volatile liquid vehicle are converted into acceptably flowing and compressible powders, by simple physical blending with s...
متن کاملEffect of Reprocessing and Excipient Characteristics on Ibuprofen Tablet Properties
Purpose: To determine excipient and ibuprofen:excipient mixture sensitivity to reprocessing produced by either direct compression or wet granulation. Methods: The effect of excipient type, technology and reprocessing on flow, compressibility and compactibility was assessed using and 8x2x2 factorial design. Design Expert® v.8.01 software was employed for data analysis. Pure excipients were proce...
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ژورنال
عنوان ژورنال: INTERNATIONAL RESEARCH JOURNAL OF PHARMACY
سال: 2013
ISSN: 2230-8407
DOI: 10.7897/2230-8407.04926